Targeting Glutathione S-transferase M4 in Ewing sarcoma

Targeting Glutathione S-transferase M4 in Ewing sarcoma

Ewing sarcoma is a malignant pediatric bone and soft tissue tumor. Although the 5-year survival rate of localized disease approaches 75%, the prognosis of metastatic and/or therapy-resistant disease remains dismal despite the wide use of aggressive therapeutic strategies. We previously reported that high expression of glutathione S-transferase M4 (GSTM4) in primary tumors correlates with poor p...

Targeting the p53 Pathway in Ewing Sarcoma

The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53 gene, with approximately 50% of all human malignancies expressing dysfunctional, mutated p53 proteins. Interestingly, genetic lesions in the TP53 gene are only observed in 10% of Ewing Sarcomas, w...

Epidemiology of Ewing ́s Sarcoma Spread of Ewing’s sarcoma

Epidemiology of Ewing ́s Sarcoma Spread of Ewing’s sarcoma

Epidemiology of Ewing ́s Sarcoma Spread of Ewing’s sarcoma